Abcam, ab176576, Anti-ISL-2 antibody [EPR12785]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal ISL-2 antibody. Suitable for WB, Flow Cyt (Intra) and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR12785,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ISL-2 also known as ISLET2 or Islet-2 is a transcription factor with an approximate mass of 39 kDa. It belongs to the LIM/homeobox family and primarily functions by binding DNA to regulate gene transcription. This protein is essential in the central nervous system and is also expressed in the developing spinal cord. In these tissues ISL-2 facilitates the differentiation and maturation of specific neuronal populations by influencing the transcription of downstream target genes.
Biological function summary
As part of a complex network of transcription factors ISL-2 plays an important role in neuronal development. It controls genes involved in motor neuron differentiation and axonal guidance. ISL-2 influences the identity and function of neurons participating in the formation of neural circuits. The protein's regulatory capacity ensures correct neuronal patterning impacting the functioning of developing and mature nervous systems.
Pathways
ISL-2 interacts with signaling pathways related to neuronal specification such as the Hedgehog and Wnt pathways. These pathways are important for the regulation of neural tube development and organization of neuronal structures. In the Wnt pathway ISL-2 interacts with proteins like β-catenin to modulate gene expression important for neuronal identity. Its involvement in these pathways reinforces the protein's function in maintaining nervous system integrity.
ISL-2 has implications in neurodegenerative diseases and spinal muscular atrophy. Mutations or dysregulation of ISL-2 expression can affect motor neuron health leading to progressive loss of motor function. It shows connections with other proteins involved in neurodegeneration such as SMN (survival motor neuron protein) which plays a role in the disease's pathology. Understanding ISL-2's regulation and interactions can offer insights into therapeutic strategies for such disorders.