Abcam, ab176578, Anti-RABEP1 antibody

Size: 100µL
Rabbit Polyclonal RABEP1 antibody. Suitable for IP, WB and reacts with Human, Mouse samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human RABEP1 aa 800 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human RABEP1 aa 800 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q15276

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab176578 was affinity purified using an epitope specific to RABEP1 immobilized on solid support., Storage buffer-pH: 6.8 - 7.4Preservative: 0.09% Sodium azideConstituents: 99% Tris buffered saline, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
RABEP1 also known as Rabaptin-5 is a protein involved in membrane trafficking processes and it has a molecular mass of approximately 101 kDa. It acts as a linker connecting Rab5 and other effector proteins. RABEP1 operates predominantly within the early endosomes where it plays a part in the regulation of endocytic pathways. The protein exhibits expression in various tissues although more investigation may be necessary to fully map its exact distribution.
Biological function summary
RABEP1 functions as a central component in early endosome fusion and trafficking processes. It often forms part of a complex with the Rab5 protein facilitating the tethering and docking of vesicles within the intracellular environment. Through its interactions it plays roles in processes such as endocytosis and recycling of membrane receptors. The RABEP1's activities ensure proper sorting and transport of cargo molecules contributing to cellular homeostasis.
Pathways
RABEP1 contributes significantly to both the endocytic and recycling pathways. It associates closely with the Rab family of GTPases particularly Rab5 during the early stages of endosomal transport. This protein helps in transitioning cargo through the endosomes an important part of the Rab5-related endocytic pathway. Also RABEP1 works collaboratively with the EEA1 protein assisting in the regulation of early endosome membrane fusion and cargo sorting.
RABEP1 shows associations with neurodegenerative and metabolic conditions. Studies link its dysfunction with Alzheimer's disease implicating its connection with tau protein aggregation. RABEP1 also reveals relationships with the insulin receptor through endosomal trafficking pathways indicating potential involvement in metabolic disorders like type 2 diabetes. Understanding these connections may open avenues for therapeutic interventions targeting these pathways.