Abcam, ab176594, Anti-ZZEF1 antibody

Size: 100µL
Rabbit Polyclonal ZZEF1 antibody. Suitable for IP and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human ZZEF1 aa 500-600.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human ZZEF1 aa 500-600. The exact immunogen used to generate this antibody is proprietary information.O43149

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: 99% Tris citrate/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ZZEF1 also known as Zinc Finger ZZ-Type with EF-Hand Domain 1 is a protein with a mass of approximately 330 kDa. This protein functions in the cell nucleus and cytoplasm and acts as a transcription factor by binding to DNA and regulating gene expression. It bears zinc finger domains and EF-hand motifs which suggest a role in DNA binding and calcium ion interaction respectively. It's expressed in various tissues including the brain liver and heart highlighting its diverse functional roles in different physiological contexts.
Biological function summary
ZZEF1 influences cell growth and differentiation by participating in transcription regulation. It integrates into multi-protein complexes that modify chromatin structure facilitating changes in gene expression. The protein plays an important part in the transcriptional control of genes responsible for cell cycle progression and apoptosis. This highlights its potential role in balancing cell proliferation and death which is fundamental in development and homeostasis.
Pathways
ZZEF1 is active in the Wnt signaling and Notch signaling pathways both essential for cell fate decisions and tissue development. Within these pathways it can interact with other transcription factors to modulate target gene expression. ZZEF1 has connections to key proteins such as β-catenin in the Wnt pathway and RBPJ in the Notch pathway indicating a collaborative role in gene expression regulation during developmental processes.
ZZEF1 impacts cancer and neurodegenerative diseases through its involvement in transcription and cell cycle regulation. Its altered expression or mutations can drive abnormal cell proliferation linking it to oncogenesis. In certain cancers it interacts with p53 a tumor suppressor protein potentially affecting cell cycle checkpoints. Additionally its dysregulation might contribute to neurodegenerative conditions where cell growth and apoptosis are disturbed suggesting a complex role in maintaining neural tissue integrity.