Abcam, ab176595, Anti-CRAMP1L antibody

Size: 100µL
Rabbit Polyclonal CRAMP1L antibody. Suitable for IP and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human CRAMP1 aa 300-350.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human CRAMP1 aa 300-350. The exact immunogen used to generate this antibody is proprietary information.Q96RY5

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab176595 was affinity purified using an epitope specific to CRAMP1L immobilized on solid support., Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: 99% Tris citrate/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CRAMP1L also known as Cathelicidin-related antimicrobial peptide 1-like is a protein involved in immune response. It has a molecular mass of approximately 18 kDa. Researchers have identified its expression mainly in epithelial cells including those in mucosal tissues like the skin and gastrointestinal tract. CRAMP1L plays a direct role in antimicrobial defense contributing to the barrier function of epithelia by disrupting bacterial membranes.
Biological function summary
CRAMP1L acts as an antimicrobial peptide directly attacking pathogens through membrane disruption. It does not function as a part of a larger complex but contributes independently to the innate immune response. It is especially important in the first line of defense against bacterial infections playing a role in neutralizing pathogens before they can cause harm. Its activity complements the broader immune system by providing immediate response capabilities.
Pathways
CRAMP1L participates in the immune response and inflammation pathways. These pathways involve interactions with toll-like receptors and influence signaling cascades such as NF-kB a central regulator of immune response genes. CRAMP1L's action and regulation relate to other antimicrobial peptides and inflammatory cytokines modulating the body's defense mechanisms. There is interaction with related proteins like LL-37 which also forms part of the innate immune roster.
CRAMP1L has significant implications for inflammatory bowel disease and psoriasis. Inflammatory bowel disease links to its role in maintaining intestinal mucosal barrier integrity where CRAMP1L's expression may be altered. Psoriasis a condition characterized by chronic skin inflammation involves abnormal levels of CRAMP1L expression. Connections to proteins like beta-defensins which also have antimicrobial activity emphasize CRAMP1L's relevance in these disorders.