Abcam, ab176707, Anti-FLCN antibody

Size: 100µL
Rabbit Polyclonal FLCN antibody. Suitable for IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human FLCN aa 1-50.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human FLCN aa 1-50. The exact immunogen used to generate this antibody is proprietary information.Q8NFG4

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab176707 was affinity purified using an epitope specific to FLCN immobilized on solid support., Storage buffer-pH: 6.8 - 7.4Preservative: 0.09% Sodium azideConstituents: 99% Tris buffered saline, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle, Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The Folliculin (FLCN) protein also known by its gene name BHD serves as a tumor suppressor and has significant roles in cellular processes. FLCN comprises 579 amino acids resulting in a molecular weight of approximately 64 kDa. It expresses in various tissues notably in the skin kidney and lung. FLCN interacts with several proteins and serves essential roles in maintaining cell stability.
Biological function summary
FLCN plays a role in energy and nutrient sensing within cells. It forms part of a complex with FNIP1 and FNIP2 proteins which helps regulate cellular growth and metabolism. This complex acts as a hub for integrating various signaling pathways influencing how cells respond to changing metabolic states.
Pathways
Research connects FLCN to the mTOR signaling pathway and AMP-activated protein kinase (AMPK) pathway which are critical for cellular metabolism and energy homeostasis. The interaction between FLCN and the mTOR pathway facilitates control over cell growth and proliferation by sensing cellular energy levels. Moreover FLCN associates with pathways that include proteins like TSC1 and TSC2 which also contribute to the regulation of these pathways.
FLCN mutations link to Birt-Hogg-Dubé syndrome a genetic disorder causing skin lung and kidney anomalies. Its dysfunction also associates with certain types of kidney cancer where FLCN's tumor suppressor role becomes evident. Altered interactions between FLCN and other proteins such as AMPK can contribute to disease progression highlighting FLCN's importance in medical research concerning cancer and genetic disorders.