Abcam, ab176794, Anti-FUT9 antibody

Size: 100µg
Rabbit Polyclonal FUT9 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human FUT9 aa 150 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human FUT9 aa 150 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q9Y231

Properties and Storage Information:
Form-Lyophilized, Reconstitution-reconstitute with water at 200µL, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The fucosyltransferase 9 (FUT9) is an enzyme that transfers fucose a hexose deoxy sugar to N-acetylglucosamine which is part of the process of glycosylation. Also known as FT9 this enzyme weighs approximately 44 kDa. It is expressed in many tissues but has higher levels in the brain. FUT9 functions to add fucose residues in the synthesis of Lewis X (LeX) antigens which are important for cell-cell interactions.
Biological function summary
The enzyme contributes to the synthesis of glycoproteins and glycolipids impacting cellular adhesion and immune response. FUT9 does not typically join with protein complexes but it plays a significant role in forming the structures essential for developmental processes. The glycan structures generated by FUT9 involve in developmental decisions and the maturation of specific cellular functions particularly in the nervous system.
Pathways
FUT9 participates actively in the N-glycan biosynthesis pathway and specifically influences the creation of the Lewis X antigen. This antigen plays a role in pathways related to leukocyte migration and neural development. In these pathways FUT9 interacts indirectly with adhesion molecules and lectins which recognize and bind to specific sugar structures like LeX affecting downstream signaling and cell movement.
FUT9 relates to certain types of cancer and neurological diseases. Altered fucosylation patterns mediated by FUT9 associate with tumor metastasis and cancer progression. In the context of neurological disorders irregular FUT9 activity correlates with conditions like Alzheimer's where cell adhesion molecules affected by FUT9-mediated fucosylation undergo alterations. This enzyme's interaction with adhesion proteins can influence disease state and severity in these cases.