Abcam, ab176809, Anti-WDR42A antibody

Size: 100µL
Rabbit Polyclonal WDR42A antibody. Suitable for IP, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human DCAF8 aa 50-100.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human DCAF8 aa 50-100. The exact immunogen used to generate this antibody is proprietary information.Q5TAQ9

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab176809 was affinity purified using an epitope specific to WDR42A immobilized on solid support., Storage buffer-pH: 6.8 - 7.4Preservative: 0.09% Sodium azideConstituents: 99% Tris buffered saline, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
WDR42A also known as WD repeat domain 42A is a protein involved in various cellular processes. With a molecular mass of approximately 38 kDa WDR42A is part of a family of proteins characterized by their WD repeats which facilitate protein-protein interactions. It expresses widely in many tissues which suggests its importance across different cellular environments. Predominantly it localizes within the nucleus where it plays roles in regulating gene expression.
Biological function summary
WDR42A contributes to cellular processes such as cell cycle progression and signal transduction. It often functions as a component of the human CTLH (C-Terminal to LisH) complex a multi-protein assembly involved in regulating protein degradation via the ubiquitin-proteasome system. This involvement highlights its role in maintaining protein homeostasis within cells and suggests interactions with other proteins in the complex may modulate these processes impacting how cells respond to various signals.
Pathways
WDR42A plays a role in the ubiquitin-mediated proteolysis pathway. It links with other proteins in the CTLH complex to facilitate tagging of proteins for degradation a critical mechanism for controlling protein levels within cells. WDR42A also interacts with proteins such as GID4 within this pathway to target specific substrates for proteolysis demonstrating its specialized contribution to cellular regulation and protein turnover.
WDR42A has connections to cancer progression and neurodegenerative diseases. Abnormalities in its function may lead to disruptions in protein degradation influencing cancer development through uncontrolled cell growth. Similarly its interaction with proteins like GID4 within the context of neurodegenerative diseases may affect the degradation of aberrant proteins leading to neuron dysfunction. Understanding WDR42A’s role offers pathways to explore therapeutic targets for these conditions.