Abcam, ab176854, Anti-SUV3L1 antibody

Size: 100µL
Rabbit Polyclonal SUV3L1 antibody. Suitable for IP, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human SUPV3L1 aa 700 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human SUPV3L1 aa 700 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q8IYB8

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab176854 was affinity purified using an epitope specific to SUV3L1 immobilized on solid support., Storage buffer-pH: 6.8 - 7.4Preservative: 0.09% Sodium azideConstituents: 99% Tris buffered saline, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SUV3L1 also known as Suppressor of Var1 3-Like 1 is an ATP-dependent RNA helicase with a mass of approximately 90 kDa. Mechanically it unwinds RNA and participates in RNA processing and surveillance ensuring the integrity of RNA molecules. SUV3L1 exhibits a wide expression pattern being found in various tissues predominantly in regions with high mitochondrial activity due to its critical role in RNA metabolism.
Biological function summary
The helicase activity of SUV3L1 plays an important role in mitochondrial RNA degradation. SUV3L1 forms a functional complex with polynucleotide phosphorylase (PNPase) and together they contribute to mitochondrial RNA processing and decay. This complex is vital for maintaining mitochondrial RNA homeostasis and ensuring proper mitochondrial function affecting mitochondrial biogenesis and energy production.
Pathways
It is involved in mitochondrial gene expression and respiratory chain assembly. In the context of regulated RNA decay pathways SUV3L1 acts alongside PNPase to maintain proper levels of mitochondrial transcripts impacting cellular energy balance. Furthermore SUV3L1 is connected to the mitochondrial DNA transcription pathway where it associates with mitochondrial transcription factor B2 (TFB2M) enhancing the stability of mitochondrial transcripts and ensuring the effective production of mitochondrial proteins.
SUV3L1 has been implicated in mitochondrial disorders and certain types of cancer. Alterations in its function can lead to disrupted mitochondrial biogenesis contributing to disorders characterized by impaired mitochondrial activity. Research shows that SUV3L1 interacts with proteins like POLRMT which is part of the mitochondrial transcription machinery linking its dysregulation to mitochondrial-related dysfunctions and tumorigenesis. Understanding these associations helps illuminate SUV3L1's role in disease pathogenesis and potential therapeutic strategies.