Abcam, ab177004, Anti-Integrin alpha V+beta 5 antibody [P1F6]

Size: 20µL-TRIAL / 200µL
Mouse Monoclonal Integrin alpha V antibody. Suitable for Flow Cyt, ICC/IF and reacts with Human samples. Cited in 17 publications.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:P1F6,
Isotype:IgG1,
Carrier free:No,
Reacts with:Human,
Applications:Flow Cyt, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
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This antibody clone is manufactured by Abcam. If you require a custom buffer formulation or conjugation for your experiments, please contact orders@abcam.com

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 6.97% L-Arginine, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Integrin alpha V beta 5 also referred to as αVβ5 or integrin alpha V is a heterodimeric protein composed of alpha V and beta 5 subunits. It has a molecular mass of approximately 210 kDa. This integrin is found on the cell surface primarily in epithelial cells such as those within the airway. The structure enables it to bind to the extracellular matrix proteins facilitating cell adhesion and signaling.
Biological function summary
Integrin alpha V beta 5 plays an essential role in angiogenesis and tissue repair. It acts as a receptor for vitronectin and fibronectin mediating cell-matrix interactions. This integrin is part of a larger integrin family which forms complexes to execute cellular adhesion and migration processes. Its ability to bind to multiple ligands highlights its flexibility in function.
Pathways
Integrin alpha V beta 5 is deeply engaged in the FAK (focal adhesion kinase) and MAPK (mitogen-activated protein kinase) pathways. These pathways are significant in cell survival proliferation and differentiation. Integrin alpha V beta 5 interacts with other proteins such as integrin beta 3 to regulate cellular responses to environmental cues linking the extracellular matrix to intracellular signaling pathways.
Integrin alpha V beta 5 has been linked to cancer progression and fibrosis. Its expression correlates with tumor invasiveness and metastatic potential by promoting angiogenesis and tissue invasion. In fibrosis it contributes to the excessive buildup of extracellular matrix. The interaction with proteins like TGF-β (transforming growth factor-beta) is notable in these disease processes influencing the pathophysiology by modulating cellular responses to growth factors.