Abcam, ab177153, Anti-MST4 antibody [EPR12766]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal MST4 antibody. Suitable for IHC-P, WB, Flow Cyt (Intra) and reacts with Human, Mouse, Rat samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR12766,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:Flow Cyt (Intra), WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
MST4 also known as mammalian sterile 20-like kinase 4 is a serine/threonine kinase with a molecular mass of approximately 53 kDa. It belongs to the germinal center kinase (GCK) family and is expressed in various tissues showing higher levels in the brain and testis. MST4 localizes to the Golgi apparatus where it plays a role in regulating cellular processes.
Biological function summary
MST4 contributes to cell growth apoptosis and stress response signaling. It does not operate alone; MST4 is a part of the STRIPAK complex. The protein involves itself in the regulation of the actin cytoskeleton thereby influencing cell motility and polarity. By modulating these processes MST4 can impact developmental and stress-induced cellular pathways.
Pathways
MST4 participates in the Hippo signaling pathway which regulates organ size by controlling cell proliferation and apoptosis. In this pathway MST4 interacts with other proteins such as MST1 and MST2 to execute its functions. MST4 also participates in the MAPK signaling pathway where it connects to various cellular stress responses contributing to the transcriptional activity of downstream effectors.
MST4 has implications in cancer and neurodegenerative diseases. Alterations in MST4 expression or activity have been associated with tumor progression in several cancers. Additionally it's linked to neurodegeneration through its interactions with proteins such as Tau where dysregulated pathways may lead to pathological conditions. These connections highlight the importance of MST4 in maintaining cellular homeostasis and the implications of its dysfunction in disease states.