Abcam, ab177155, Anti-Striatin 4 antibody [EPR11801]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal Striatin 4 antibody. Suitable for IP, WB, ICC/IF, Flow Cyt (Intra) and reacts with Human samples. Cited in 4 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR11801,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICC/IF, IP, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Species reactivity
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.
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contact us
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Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Striatin 4 also known as SG2NA or STRN4 is a scaffold protein with a molecular mass of approximately 100 kDa. It is part of the striatin family and plays an important role in the organization of multiprotein complexes. The protein is expressed in several tissues including the brain where it influences signaling pathways. Striatin 4 interacts with calmodulin and phosphatases facilitating communication and modification of signaling proteins.
Biological function summary
Striatin 4 facilitates interactions within the striatin family interactosome and contributes to the modulation of calcium signaling through its role in calcium/calmodulin-dependent processes. As a regulatory component it is essential within protein complexes that have wide implications in cellular signaling. The protein supports roles in cell growth apoptosis and vascular function due to its ability to bring together various signaling proteins and enzymes impacting cellular behavior.
Pathways
Researchers have identified Striatin 4 as a participant in important pathways that include the protein phosphatase 2A (PP2A) pathway and the calcium signaling pathway. Its interactions with PP2A-related proteins suggest it may serve to regulate protein dephosphorylation events thereby affecting many downstream signaling cascades. Through its participation in calcium signaling Striatin 4 works in conjunction with calcium-binding proteins influencing various physiological processes such as muscle contraction and neurotransmitter release.
Studies have linked Striatin 4 to conditions such as Alzheimer's disease and cardiovascular disorders where its role in signaling pathways may contribute to pathological changes. Its association with proteins like tau in Alzheimer's reflects its potential influence on neurodegenerative processes. Additionally the interaction of Striatin 4 with vascular-related proteins could implicate it in the progression of cardiovascular conditions making it a target of interest for disease understanding and therapeutic development.