Abcam, ab177952, Anti-NCX1 antibody [EPR12739]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal NCX1 antibody. Suitable for WB and reacts with Mouse, Rat, Human samples. Cited in 24 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR12739,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
NCX1 also known as the Sodium-Calcium Exchanger 1 plays a critical role in removing calcium ions from cells by exchanging them for sodium ions. It operates as an antiporter mechanism facilitating the transport of three sodium ions into the cell in exchange for one calcium ion being transported out. The protein has a molecular mass of approximately 120 kDa. NCX1 is widely expressed in various tissues including heart brain kidney and skeletal muscle indicating its importance in multiple physiological processes.
Biological function summary
NCX1 contributes significantly to controlling intracellular calcium levels important for muscle contraction and neuronal function. The protein forms part of a larger complex that includes several regulatory proteins which modulate its activity according to the cellular environment. By managing calcium ion concentration inside cells NCX1 influences various cellular processes such as muscle relaxation and excitatory signaling in neurons.
Pathways
NCX1 integrates itself into the cellular calcium homeostasis and cardiac excitation-contraction coupling pathways. In the cardiac tissue it works alongside other proteins like the L-type calcium channel contributing to the regulation of the heart’s rhythm and contraction force. Another pathway involves its interaction with the sodium-potassium ATPase which helps maintain the cell's electrochemical gradient essential for proper muscle and nerve function.
NCX1 has been linked to cardiovascular diseases such as heart failure and arrhythmias. Abnormal NCX1 function can disrupt calcium balance leading to these conditions. Moreover the protein's relationship with the L-type calcium channel is important because alterations in their interaction can exacerbate such cardiovascular disorders. Additionally NCX1 has connections to disorders like epilepsy where other ion channels and transporters also play critical roles in maintaining neural excitability and preventing seizure activities.