Abcam, ab178690, Anti-TAF1C antibody [EPR11298]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal TAF1C antibody. Suitable for IP, WB and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR11298,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Species reactivity
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.
Please
contact us
for more information.
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TAF1C also known as Transcription Initiation Factor TFIID Subunit 1C is a component of the transcription factor complex that plays an important role in the initiation of transcription by RNA polymerase I. It has a molecular mass of approximately 64 kDa. TAF1C is mainly expressed in the nucleolus of eukaryotic cells where it aids in forming the transcription preinitiation complex. The protein interacts specifically with other subunits to enable the RNA polymerase I to initiate the transcription of ribosomal RNA genes.
Biological function summary
TAF1C is essential for assembling the RNA polymerase I complex often referred to as the SL1 complex. This complex includes other components like TBP and several TAFs which together promote the transcription of rRNA genes critical for ribosome biogenesis. By participating in the formation of this complex TAF1C impacts cellular growth by influencing ribosome production. The functional activity of TAF1C thereby strongly ties to cellular metabolism given its position in rRNA transcription machinery.
Pathways
TAF1C is involved in the rRNA synthesis pathway a pathway important for ribosome production. This pathway interfaces with the cell growth and division pathways with proteins like TBP and other transcription factors forming significant parts of these linked networks. TAF1C contributes to maintaining cellular homeostasis by its functions in these pathways impacting how cells respond and adapt to metabolic demands and growth signals.
TAF1C has connections to diseases like cancer due to its involvement in ribosome biogenesis. Altered expression of TAF1C affects nucleolar activity which is often observed in tumor cells. Moreover any disruption in its function can lead to dysregulation of rRNA synthesis linking it indirectly to p53 a protein involved in cell cycle regulation and apoptosis. Aberrant regulation or mutations in TAF1C-related pathways may fuel disease progression and are subjects of current research interest in oncology.