Abcam, ab178858, Anti-JunD (phospho S100) + c-Jun (phospho S73) antibody [EPR16586]

Size: 20µL / 100µL / 1mL
Rabbit Recombinant Monoclonal c-Jun phospho S73 antibody. Suitable for IP, Dot, WB, IHC-P and reacts with Human, Mouse, Rat samples. Cited in 4 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR16586,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:IHC-P, Dot, IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
JunD and c-Jun are transcription factors belonging to the AP-1 (Activator Protein-1) family. These proteins are important for regulating gene expression in response to a variety of stimuli. JunD is approximately 39 kDa while c-Jun is a bit smaller at approximately 35 kDa. Both proteins are expressed in various tissues including the heart brain and liver. Complexes formed by binding of these proteins with other family members like Fos Jun and ATF lead to changes in transcription activity.
Biological function summary
JunD and c-Jun influence cell proliferation differentiation and apoptosis. They frequently form homodimers or heterodimers particularly in cooperation with proteins like c-Fos for regulating target gene expression. JunD and c-Jun modulate cell cycle-related genes and interact with signaling molecules to control cellular responses impacting the balance between cell survival and programmed cell death.
Pathways
JunD and c-Jun play a central role in the MAPK (Mitogen-Activated Protein Kinase) signaling pathway a critical pathway for transducing extracellular signals into various cellular responses. In this pathway JunD and c-Jun phosphorylation influences their activity. These proteins associate with other factors such as c-Fos to regulate gene expression related to stress responses and immune function. They also participate in the JNK (c-Jun N-terminal kinase) pathway further emphasizing their role in cell fate decisions.
Abnormal JunD and c-Jun activity relate to cancer and neurodegenerative diseases. In certain cancers overexpression or mutations lead to uncontrolled cell proliferation due to altered gene transcription. In the neurological context dysregulation of these proteins associates with disorders like Alzheimer's disease where improper neuronal apoptosis occurs. In both scenarios their interaction with other proteins such as c-Fos underlines their importance in pathological conditions.