Abcam, ab180134, Anti-PTPRR/PCPTP1 antibody [EPR13188]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal PCPTP1/PTPRQ antibody. Suitable for WB and reacts with Human, Mouse, Rat samples. Cited in 2 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR13188,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The protein tyrosine phosphatase receptor type R (PTPRR) also known as PCPTP1 acts as a signaling molecule that regulates phosphorylation states in various cellular processes. The molecular mass of PTPRR is approximately 72 kDa. PTPRR predominantly expresses in the nervous system especially in the brain and cerebellum where it influences neuronal signaling pathways. Its role in the modulation of kinase activity highlights its importance in cellular function.
Biological function summary
PTPRR regulates the activity of mitogen-activated protein kinases (MAPKs) critical elements of intracellular signaling. PTPRR functions as part of multiprotein complexes involving MAPKs affecting their dephosphorylation and inactivation. This modulation influences several cellular responses such as cell growth differentiation and development asserting a significant role in neurophysiological processes.
Pathways
The PTPRR protein plays a role in the MAP kinase signaling pathway and the JNK pathway. By interacting with MAPKs like ERK it helps modulate the transmission of extracellular signals to cellular responses ensuring the appropriate cellular outcome. PTPRR through these pathways relates with other tyrosine phosphatases and interacts with adaptor proteins contributing to signal transduction fidelity and complexity.
Alterations in PTPRR function connect to neurological and psychiatric conditions. Dysregulation of PTPRR can lead to abnormal brain function with associations to disorders like schizophrenia and certain neurodegenerative diseases. Through these disease contexts PTPRR links with other phosphatases such as DUSP6 and MAP kinases highlighting its role in maintaining neuronal health and its potential as a therapeutic target.