Abcam, ab18038, Anti-SMC5 antibody

Size: 100µg
Rabbit Polyclonal SMC5 antibody. Suitable for IP, WB and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Synthetic Peptide within Human SMC5 aa 1050 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human SMC5 aa 1050 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q8IY18

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-Antibody was purified using an epitope specific to SMC5 immobilized on solid support., Storage buffer-pH: 7 - 8Preservative: 0.1% Sodium azideConstituents: PBS, 1.815% Tris, 1.764% Sodium citrate, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle, Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SMC5 also known as Structural Maintenance of Chromosomes 5 is a protein that plays a significant role in chromosome segregation and stability. It has a molecular mass of approximately 122 kDa. This protein is widely expressed in many tissues with high levels observed in the brain liver and lung. SMC5 is a part of the SMC protein family and functions in connection with SMC6 forming the SMC5/6 complex. This complex is necessary for DNA repair and recombination processes.
Biological function summary
SMC5 influences the maintenance of genomic integrity during cell division. It is an essential component of the SMC5/6 complex which also includes non-SMC proteins like NSMCE1-4. The complex facilitates proper segregation of chromosomes by stabilizing replication forks and resolving DNA interlinkages. This mechanism is key in preventing genomic instability which can lead to diverse cellular dysfunctions.
Pathways
SMC5 is involved in the DNA damage response and homologous recombination repair pathways. It interacts with proteins like RAD51 which plays a role in the repair of double-strand breaks through homologous recombination. These pathways ensure that damaged DNA is accurately repaired preventing erroneous sequences from propagating during subsequent cell divisions.
SMC5 has been linked to conditions such as cancer and Fanconi anemia. Mutations affecting the SMC5/6 complex can lead to defective DNA repair and accumulated genomic instability often observed in cancers. The complex's disruption also relates to Fanconi anemia a disorder that affects bone marrow function. There are associations with proteins like BRCA1 and FANCI both of which participate in the cellular response to DNA damage and repair highlighting the complex's medical relevance.