Abcam, ab180598, Anti-PGBD1 antibody [EPR13883]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal PGBD1 antibody. Suitable for WB, ICC/IF, Flow Cyt (Intra) and reacts with Human samples. Cited in 2 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR13883,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICC/IF, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
PGBD1 also known as PiggyBac Transposable Element-Derived 1 is a DNA transposase-like protein. The human PGBD1 protein has a molecular mass of approximately 98 kDa. It is a member of the piggyBac family of transposases and is highly expressed in the brain and various other tissues. PGBD1 has a sequence that shows homology to known active transposases but lacks the catalytic triad of DDD signature suggesting a more complex role beyond simple transposition mechanics.
Biological function summary
The gene encoding PGBD1 is involved in processes related to genomic stability and chromatin remodeling although it does not form part of a known multiprotein complex. This protein plays roles in gene expression regulation and might affect chromatin through non-transposase activity. It is hypothesized that PGBD1 might bind to specific DNA sequences impacting chromatin state and gene activity. Its exact biological function remains under investigation but the regulation of neural-related genes implicates a role in neural tissue development and maintenance.
Pathways
PGBD1 is involved in the regulation of chromatin structure and gene expression pathways. Its interactions influence pathways like the DNA damage response contributing to cellular reactions to stress at the genetic level. The protein may not operate alone but has functional associations with chromatin remodelers such as Polycomb group proteins which are important in managing gene expression patterns during development and differentiation.
Dysregulation or mutations of PGBD1 suggest potential links with neurodevelopmental disorders and cancer. Altered expression patterns have been noted in neuroblastoma implying interactions with proteins like MYCN an important oncogene. PGBD1's effect on chromatin dynamics could influence the genomic environment leading to disease-associated changes in gene expression. Further research seeks to clarify these connections and determine potential therapeutic targets or biomarkers.