Abcam, ab180605, Anti-BTN1A1 antibody [EPR14173]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal BTN1A1 antibody. Suitable for IP, WB and reacts with Human samples. Cited in 2 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR14173,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purity-Tissue culture supernatant, Storage buffer-Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
BTN1A1 also known as Butyrophilin Subfamily 1 Member A1 is a type I transmembrane protein with a molecular mass of approximately 57 kDa. It is a member of the immunoglobulin superfamily and expressed in various tissues with notably high expression in the mammary gland during lactation. BTN1A1 plays a significant role in milk fat globule secretion by forming complexes on the apical surface of mammary epithelial cells. The protein consists of an extracellular region a transmembrane domain and a cytoplasmic tail.
Biological function summary
As a component of the milk fat globule membrane BTN1A1 participates in lipids metabolic processes and immunological interactions. It does not function as part of a large protein complex yet its interactions on the cell surface are essential for the stability and transport of fat globules. The presence of BTN1A1 impacts immune cell regulation due to its predicted involvement with T cells an important component of the adaptive immune system.
Pathways
BTN1A1 contributes to both lactation and immune regulation processes. It is particularly involved in the fatty acid metabolism pathway impacting lipid biosynthesis and transport. Within immune regulation pathways BTN1A1 might interact with related proteins such as BTN2A1 also in the butyrophilin family which modulates T cell activity. These pathway involvements reflect BTN1A1's dual role in lipid homeostasis and immune surveillance.
BTN1A1 has a potential link to breast cancer and certain autoimmune diseases. Given its expression in the mammary gland altered levels of BTN1A1 might associate with breast tumor development. Additionally its role in immune regulation suggests a connection to autoimmune disorders where improperly modulated T cell responses occur. Further research is necessary to completely understand the protein's involvement in these diseases and any interaction with proteins like BTN2A1 in pathological contexts.