Abcam, ab180757, Anti-Solute carrier family 22 member 5 antibody

Size: 100µL
Rabbit Polyclonal Solute carrier family 22 member 5 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human, Mouse samples. Cited in 8 publications. Immunogen corresponding to Recombinant Fragment Protein within Human SLC22A5 aa 1-200.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:IHC-P, ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human SLC22A5 aa 1-200. The exact immunogen used to generate this antibody is proprietary information.O76082

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.3Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Solute carrier family 22 member 5 (SLC22A5) also known as OCTN2 is a transporter protein with a molecular mass of approximately 62 kDa. It facilitates the uptake of organic cations and carnitine a type of amino acid derivative into cells. SLC22A5 is expressed widely in tissues with notable presence in skeletal muscle heart kidney intestine and placenta where it plays a significant role in cellular nutrition and detoxification processes.
Biological function summary
SLC22A5 functions to maintain carnitine homeostasis in the body. Carnitine is essential for the transport of long-chain fatty acids into the mitochondria for β-oxidation therefore providing cellular energy. SLC22A5 is a component of the carnitine transport system and interacts directly with other transporters and enzymes involved in the carnitine pathway. It is responsible for mediating the uptake and efflux of L-carnitine and acyl-carnitines across the cell membrane.
Pathways
The involvement of SLC22A5 in fatty acid metabolism is significant. It importantly participates in the carnitine shuttle allowing fatty acids to enter the mitochondria which is integral to energy production via fatty acid β-oxidation. SLC22A5 is linked with the long-chain fatty-acid-CoA ligase proteins which activate fatty acids prior to mitochondrial uptake. The interaction with these proteins ensures efficient energy production in response to cellular demands.
Defective SLC22A5 function is associated with systemic primary carnitine deficiency (CDSP) a disorder characterized by impaired cellular energy metabolism. This deficiency results from a loss of function mutations in the SLC22A5 gene leading to deficient carnitine transport and accumulation of fatty acids in tissues. Additionally SLC22A5 interactions with proteins involved in energy metabolism may play a role in metabolic syndromes as energy imbalance can contribute to the clinical manifestations of these disorders.