Abcam, ab181072, Anti-PSMD7/Mov34 antibody [EPR13517]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal PSMD7/Mov34 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR13517,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purity-Tissue culture supernatant, Storage buffer-Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The PSMD7 protein also known as Mov34 is a subunit of the 26S proteasome and plays an important role in protein degradation. The proteasome itself is a massive complex and PSMD7 is a 37 kDa protein component. Its primary site of expression is within the cytoplasm and nucleus of cells where it facilitates the breakdown of ubiquitinated proteins. This activity is essential for maintaining cellular protein homeostasis.
Biological function summary
The proper function of PSMD7 supports cell cycle regulation apoptosis and DNA damage repair. It exists as part of the 26S proteasome complex which is responsible for the regulated degradation of ubiquitin-conjugated proteins. This process controls various cellular mechanisms by ensuring that proteins are broken down after they have executed their function or if they become misfolded or damaged.
Pathways
The involvement of PSMD7 in proteolysis is central for processes such as the ubiquitin-proteasome pathway. This pathway is critical for protein turnover and the regulation of cellular processes including the cell cycle. PSMD7 works in tandem with other proteasomal subunits like PSMD4 and PSMD14 which help recruit and process ubiquitinated substrates.
The malfunction of PSMD7 associates with certain cancers and neurodegenerative diseases. Aberrations in proteasome function involving PSMD7 may lead to the accumulation of damaged proteins which contributes to cancer development through unchecked cell proliferation. In neurodegenerative disorders like Alzheimer's disease proteins like tau and beta-amyloid which should normally be degraded accumulate due to proteasomal dysfunction involving PSMD7.