Abcam, ab181076, Anti-SEC22B antibody [EPR12335]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal SEC22B antibody. Suitable for IP, WB, ICC/IF, Flow Cyt (Intra) and reacts with Human, Mouse, Rat samples. Cited in 5 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR12335,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:ICC/IF, WB, IP, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Specificity:The rat recommendation is based on the WB results. We do not guarantee IHC-P for rat.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SEC22B also known as SEC22 homolog B is a membrane protein involved in vesicular trafficking within cells. It plays an important role in the transport between the endoplasmic reticulum (ER) and the Golgi apparatus. SEC22B belongs to the SNARE (soluble NSF attachment protein receptor) family with a molecular mass of approximately 29 kDa. It is expressed in various tissues with prominent presence in the immune system and neuronal tissues. The protein participates in the assembly of vesicle transport machinery important for proper cellular function and compartmentalization.
Biological function summary
SEC22B contributes to the fusion of transport vesicles with target membranes. It acts as part of a SNARE complex facilitating vesicle docking and subsequent membrane fusion through protein-protein interaction. In immune cells SEC22B is essential for antigen presentation. It regulates the trafficking of peptide-MHC complexes to the cell surface essential for adaptive immune response. In neurons the protein ensures efficient neurotransmitter release by managing vesicle cycling and synaptic vesicle fusion.
Pathways
SEC22B integrates into the vesicular transport and secretory pathways. It operates in the ER-Golgi transport route critical in maintaining cellular homeostasis and protein processing. The function of SEC22B involves interaction with other SNARE proteins like VAMP7 and SNAP23 forming SNARE complexes that drive membrane fusion events. This protein also influences the Golgi-to-ER retrograde transport contributing to the protein sorting pathway that recycles specific proteins back to the ER.
SEC22B links closely to immune-related conditions and neurodegenerative diseases. Disruption in SEC22B function can impact antigen presentation and immune system efficiency potentially contributing to autoimmune disorders. In neurological contexts altered SEC22B activity may interfere with neurotransmitter release possibly playing a role in conditions such as Alzheimer's disease. Connections with proteins like VAMP7 underline the importance of SEC22B in maintaining cellular integrity across different systems.