Abcam, ab181082, Anti-RBMS3+ RBMS1 antibody [EPR12905]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal RBMS1 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR12905,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Specificity:Immunogen also corresponds to amino acids 102 -114 of RBMS3 (Q6XE24).

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purity-Tissue culture supernatant, Storage buffer-Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
RBMS3 and RBMS1 are members of the RNA-binding motif single-stranded interacting protein family known for their role in nucleic acid binding. RBMS3 often referred to as RNA-binding motif single-stranded-interacting protein 3 possesses a molecular mass of approximately 43 kDa. RBMS1 shares a similar domain structure targeted as an RNA-binding protein. These proteins express in various tissues including the liver heart and lungs with significant levels in the brain and kidneys. Both RBMS3 and RBMS1 play a part in regulating cellular proliferation and have been linked to the stabilization of specific mRNA transcripts.
Biological function summary
RBMS3 and RBMS1 take part in processes that impact cell growth apoptosis and differentiation. They involve themselves in RNA metabolism where they can influence mRNA stability and transcription. In terms of complex formation they associate with other factors to regulate transcription and influence gene expression. They help control genes involved in cellular growth responses and have implications for maintaining cellular homeostasis.
Pathways
RBMS3 and RBMS1 contribute to the regulation of the cell cycle and apoptosis. They participate in the Wnt signaling pathway a critical route for cell proliferation and fate determination. In connection with this pathway they interact with proteins such as beta-catenin which is essential for transmitting signals within the Wnt pathway. These proteins also influence other signaling cascades that affect cellular growth and differentiation.
RBMS3 and RBMS1 show significant influence in cancer and fibrosis. Their misregulation associates with oncogenic processes where they can contribute to abnormal cell proliferation linked to various cancers. They interact with p53 a well-known tumor suppressor protein whose pathway mutations are common in cancer types. RBMS3 and RBMS1 have been implicated in tissue fibrosis where improper cell growth and response lead to the pathological development of fibrotic tissues. Their expression patterns and interactions make them significant in understanding complex changes in diseased states.