Abcam, ab181098, Anti-RBPMS2 antibody [EPR13121-79]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal RBPMS2 antibody. Suitable for IP, WB and reacts with Human, Mouse, Rat samples. Cited in 2 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR13121-79,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The RNA-binding protein with multiple splicing 2 commonly known as RBPMS2 or HERMES plays an important mechanical role as a regulator of RNA processing. With a molecular mass of approximately 25 kDa RBPMS2 acts in various tissues including heart eye and smooth muscle cells. Its expression is often specific and changes dynamically during development and in response to different cellular signals hinting at a control function in tissue-specific gene expression.
Biological function summary
By binding to RNA RBPMS2 influences mRNA stability and splicing directly affecting gene expression levels in cells. RBPMS2 is known to be involved in the formation of complexes with other proteins that regulate RNA splicing and transport. Its involvement in these complexes emphasizes its contribution to maintaining proper cellular function and development which is critical in the context of muscle tissue and eye development.
Pathways
RBPMS2 participates in essential signaling pathways such as Wnt signaling and TGF-beta signaling where it interacts with components vital for transcriptional regulation and cytoskeletal organization. This protein's interactions with factors like SMADs in the TGF-beta pathway and beta-catenin in the Wnt pathway help modulate key events in cell proliferation and differentiation illustrating its integrative role in cellular signaling networks.
Studies suggest that RBPMS2 is linked to conditions such as cataracts and cardiomyopathies. Mutations or dysregulation in RBPMS2 expression can disrupt normal cellular activities contributing to disease progression. Protein interactions such as those with SMAD family are significant in understanding its role in abnormal tissue development and associated pathologies offering potential insights into therapeutic intervention strategies.