Abcam, ab181121, Anti-RPUSD3 antibody [EPR12911]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal RPUSD3 antibody. Suitable for WB, ICC/IF, Flow Cyt (Intra) and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR12911,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, Flow Cyt (Intra), WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purity-Tissue culture supernatant, Storage buffer-Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
RPUSD3 also known as RNA pseudouridylate synthase domain containing 3 is an enzyme involved in RNA modification. This protein has a mass of approximately 60 kDa and exhibits expression in various tissues including the brain heart and skeletal muscle. The enzyme plays a role in catalyzing the isomerization of uridine to pseudouridine in RNA molecules an important step for RNA stability and function.
Biological function summary
RPUSD3 contributes to the modification of ribosomal RNA (rRNA) enhancing its structural stability and translation fidelity. This protein operates as part of a ribonucleoprotein complex engaging with other molecules to facilitate the precise modification processes necessary for proper RNA function. These modifications are important for cellular health and protein biosynthesis.
Pathways
The enzymatic activity of RPUSD3 integrates into the RNA modification pathway influencing an important process for gene expression regulation. It works alongside proteins like dyskerin which also participates in pseudouridine synthesis within the small subunit processome. This involvement positions RPUSD3 as a significant player in rRNA processing ensuring the correct assembly of ribosomes.
Alterations in RPUSD3 activity have been connected to certain neurodevelopmental disorders. Research suggests that abnormal RPUSD3 function may contribute to intellectual disability where it is seen to interact with proteins involved in neuronal development such as FMRP. Additionally this protein's altered activity associates with metabolic disorders which highlights its relevance to maintaining normal metabolic processes.