Abcam, ab181132, Anti-ZPI antibody [EPR12072]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal ZPI antibody. Suitable for IP, WB and reacts with Human samples. Cited in 2 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR12072,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ZPI also known as Protein Z-dependent protease inhibitor is a serine protease inhibitor with a mass of approximately 72 kDa. It inhibits factor Xa in a process that requires Protein Z and calcium ions. ZPI is mainly expressed in the liver and its presence has been noted in plasma. Structurally ZPI acts by forming a complex with factor Xa in the presence of protein Z leading to the inactivation of the coagulation pathway's enzymatic activity effectively reducing clot formation under physiological conditions.
Biological function summary
ZPI plays a significant role in the regulation of hemostasis controlling blood clot formation by inhibiting excess factor Xa activity. This inhibition prevents unnecessary clotting maintaining fluidity and preventing vascular occlusion. ZPI is particularly important in the context of the coagulation cascade where it forms part of a complex with Protein Z and calcium ions offering a fine balance to the procoagulant processes mediated by thrombin and factor Xa.
Pathways
The actions of ZPI largely influence the intrinsic and extrinsic coagulation pathways. Its primary function is to regulate the activity of factor Xa significantly impacting the common pathway of coagulation. Through these pathways ZPI is closely related to proteins like factor VIIa and factor IXa participating in a delicate interplay necessary for maintaining hemostatic balance and preventing thrombosis or hemorrhage.
ZPI's functional integrity is linked to conditions such as thrombophilia where an inability to effectively inhibit factor Xa can lead to increased thrombotic events. Furthermore deficiencies or malfunctions of ZPI have been associated with a heightened risk of venous thromboembolism (VTE). Altered interactions between ZPI and protein Z or factor Xa can contribute to these conditions highlighting the importance of balanced protease inhibitor activity in maintaining vascular health.