Abcam, ab181173, Anti-kur antibody [EPR13320-66]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal kur antibody. Suitable for IP, WB, ICC/IF and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR13320-66,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IP, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purity-Tissue culture supernatant, Storage buffer-Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Kur also known as the voltage-gated potassium channel subunit Kv3.x is an integral membrane protein involved in potassium ion transport across cell membranes. With a molecular mass of approximately 85 kDa this channel exhibits a high expression level in central nervous system tissues particularly in neurons. It plays a critical role in modulating neuronal excitability and signal transmission by facilitating rapid repolarization of the action potential.
Biological function summary
The voltage-gated potassium channel Kv3.x influences neurotransmitter release and neuronal firing rate. This target does not function alone; rather it forms a part of a larger channel complex. Through these channels Kv3.x regulates the rapid spike frequency adaptation enabling neurons to maintain high-frequency firing without depolarization block. By contributing to electrical signaling precision it supports diverse neuronal circuit activities.
Pathways
The potassium channel Kv3.x integrates into the neuronal excitability pathway affecting both synaptic transmission and plasticity. It interacts with key proteins like Nav1.6 a voltage-gated sodium channel as they complement each other's roles in action potential propagation. Kv3.x also participates in the broader potassium ion homeostasis pathway which involves other ion channels and transporters to maintain neuronal ion balance and function.
Dysregulation of Kv3.x channels associates with neurological conditions such as epilepsy and schizophrenia. Altered expression or function of Kv3.x can lead to increased neuronal excitability contributing to seizure susceptibility in epilepsy. In schizophrenia abnormal Kv3.x activity could disrupt normal auditory processing potentially through interactions with proteins like NMDA receptors. These associations highlight the importance of Kv3.x in maintaining neural health and signaling fidelity.