Abcam, ab181200, Anti-RPL14 antibody [EPR12301]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal RPL14 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 7 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR12301,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The RPL14 protein also known as ribosomal protein L14 plays an important role in the ribosomal 60S subunit which is essential for protein synthesis. This protein has a molecular weight of around 15 kDa and is primarily expressed in the cytoplasm. As a component of the ribosome RPL14 contributes to the structure and stability of ribosomal RNA facilitating the translation process.
Biological function summary
Ribosomal protein L14 integrates into the large ribosomal subunit participating in the assembly of the ribosome complex. RPL14 binds to 28S rRNA and contributes to the ribosome’s ability to accurately synthesize proteins. It works alongside other ribosomal proteins and RNA to ensure efficient translation of messenger RNA (mRNA) into proteins impacting cell growth and proliferation.
Pathways
RPL14 has significant involvement in the translation pathway critical for genetic expression and protein synthesis. It interacts with other ribosomal proteins within the translation machinery such as RPL5 and RPL11 to facilitate the binding of the aminoacyl-tRNA to the ribosome. In the context of the mTOR signaling pathway RPL14 potentially influences cell growth and metabolism by regulating protein synthesis rates.
The dysfunction of ribosomal protein L14 associates with certain ribosomopathies which are disorders caused by ribosomal dysfunction. Mutations or altered expression of RPL14 can also relate to cancer where deregulated protein synthesis contributes to uncontrolled cell proliferation. The interaction of RPL14 with other ribosomal proteins like RPL11 suggests its involvement in the maintenance of genomic integrity further linking it to disease states characterized by disrupted cellular homeostasis.