Abcam, ab181204, Anti-ACSM2A antibody [EPR13330]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal ACSM2A antibody. Suitable for IP, WB, IHC-P and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR13330,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ACSM2A also known as acyl-CoA synthetase medium-chain family member 2A is an enzyme that activates medium-chain fatty acids by converting them into acyl-CoA derivatives. It has a molecular mass of approximately 63 kDa. This enzyme expresses in liver and kidney tissues where it plays a significant role in lipid metabolism by facilitating the utilization of medium-chain fatty acids.
Biological function summary
ACSM2A catalyzes the formation of acyl-CoA from free fatty acids ATP and coenzyme A. It belongs to the acyl-CoA synthetase family which includes enzymes that are essential for fatty acid metabolism. While not explicitly part of a larger enzymatic complex ACSM2A interacts with other members of this family to modulate fatty acid activation and energy production.
Pathways
ACSM2A significantly contributes to beta-oxidation and the fatty acid metabolic process. It works closely with enzymes like CPT1A (carnitine palmitoyltransferase 1A) in the mitochondria to ensure efficient transport and oxidation of fatty acids. In these pathways ACSM2A's activity is vital for maintaining energy balance and regulating lipid levels within the cell.
Mutations or dysregulations of ACSM2A may associate with metabolic conditions such as obesity and diabetes mellitus. Its connection to obesity involves interactions with proteins like PPARα (peroxisome proliferator-activated receptor alpha) which regulates lipid metabolism and energy homeostasis. Altered expressions of ACSM2A can impact these metabolic pathways influencing disease progression.