Abcam, ab181247, Anti-IER3IP1 antibody [EPR13440]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal IER3IP1 antibody. Suitable for IP, WB, ICC/IF, Flow Cyt (Intra), IHC-P and reacts with Human samples. Cited in 2 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR13440,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, Flow Cyt (Intra), IP, WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
IER3IP1 also known as Immediate Early Response 3 Interacting Protein 1 is a small protein with a mass of approximately 11 kDa. It primarily localizes within the endoplasmic reticulum (ER) and shows expression in various tissues including the brain liver and pancreas. IER3IP1 plays a mechanical role in protein trafficking and the regulation of ER stress affecting cellular responses to environmental changes.
Biological function summary
IER3IP1 participates in processes related to cellular stress response and protein folding. It acts as a component involved in maintaining ER function possibly engaging in a protein complex to modulate its activity. This modulation is essential for controlling apoptosis and cell survival suggesting its involvement in critical cellular processes. The protein's interactions help sustain proper protein synthesis and folding within the ER.
Pathways
IER3IP1 interacts within the unfolded protein response pathway maintaining ER homeostasis. It engages with proteins like GRP78 and ATF6 which are significant in managing ER stress and protein folding pathways. These interactions demonstrate IER3IP1's importance in cellular mechanisms that protect cells from stress-induced damages.
Mutations or misregulation of IER3IP1 correlate with microcephaly and epilepsy. Research indicates its connection with proteins involved in neurodevelopmental disorders possibly interacting with molecules like Reelin or Dystrophin. This relationship highlights the significance of IER3IP1 in maintaining neural cell health and suggests its potential as a target for therapeutic strategies.