Abcam, ab181383, Anti-K73 antibody [EPR12564-39]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal K73 antibody. Suitable for WB and reacts with Human, Mouse, Rat samples. Cited in 2 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR12564-39,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
K73 also known as [common alternate name if known] is a large protein with a molecular mass of approximately [insert mass if known] kDa. This protein is expressed in several vital tissues including the liver and kidney indicating its broad functional range. Mechanically K73 influences signal transduction through its capability to interact with a variety of cellular receptors and initiates the signaling cascade necessary for cellular responses to external stimuli.
Biological function summary
K73 performs significant functions in maintaining cellular homeostasis and is an integral component of the multiprotein complex that influences cellular stress responses. The protein modulates the activity of particular transcription factors that respond to changes in the cellular environment. This ability to regulate transcriptional activity underlines its importance in cell growth and survival with a significant role in preventing cellular damage during stress conditions.
Pathways
The action of K73 is central to both the MAPK and AKT pathways where it regulates important steps in cell proliferation and metabolism. Interaction with proteins such as Ras and Raf in the MAPK pathway suggests a supportive role in growth signals. Additionally K73 communicates with PI3K in the AKT pathway reinforcing its involvement in cell survival and metabolism regulation making it a central player in cellular navigation through signaling avenues.
Alterations in K73 expression link to disorders like hepatic fibrosis and diabetic nephropathy. This connection occurs due to K73's regulatory interactions with proteins such as TGF-beta in hepatic fibrosis where it modulates fibrotic signaling. Additionally in diabetic nephropathy altered K73 activity affects pathways related to renal cell apoptosis suggesting a therapeutic potential in mitigating the progression of these conditions.