Abcam, ab181972, Anti-SLBP antibody [EPR12673]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal SLBP antibody. Suitable for IP, WB, Flow Cyt (Intra) and reacts with Human samples. Cited in 8 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR12673,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:Flow Cyt (Intra), WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Stem-loop binding protein (SLBP) also known as histone stem-loop binding protein is critical in the processing and regulation of histone mRNA. SLBP is a 31 kDa protein and it is found in the nucleus where it facilitates histone mRNA processing specifically the maturation and stabilization of histone pre-mRNA. This protein binds to the stem-loop structure found at the 3’ end of replication-dependent histone mRNA which is essential for proper histone production during the S phase of the cell cycle.
Biological function summary
Stem-loop binding protein interacts with histone pre-mRNA processing machinery. It is not part of any large complex but plays an important role in association with the 3' end processing mechanism. By binding the stem-loop structure SLBP participates in ensuring the stability of histone mRNA ultimately influencing histone protein synthesis. The regulation of these mRNAs is important for DNA packaging and chromosome stability which are critical processes for normal cell function and division.
Pathways
SLBP is involved in the histone mRNA processing pathway which is pivotal for eukaryotic cell replication. This pathway includes notable participants like the U7 small nuclear ribonucleoprotein (snRNP). SLBP influences the balance of histone proteins in relation to DNA synthesis. The correct function in this pathway maintains the balance between DNA replication and nucleosome assembly which is related to the cell cycle and genome integrity maintenance.
Irregularities in SLBP function or expression link to certain cancers such as breast cancer where abnormal histone mRNA processing can occur. It is also associated with developmental disorders due to its role in cell division and DNA replication. In cases of cancer SLBP interacts with proteins like the p53 pathway where disruptions can lead to uncontrolled cell proliferation and tumor growth.