Abcam, ab182007, Anti-DDX41 antibody [EPR14298]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal DDX41 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 2 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR14298,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The DDX41 protein also known as DEAD Box Protein 41 is a member of the DEAD-box RNA helicase family. This protein weighs approximately 82 kDa. It is involved in various RNA processing activities including alteration of RNA secondary structure during spliceosome assembly ribosome biogenesis and RNA transport. DDX41 is expressed in a wide range of tissues with particularly high levels in bone marrow and immune cells. By functioning as an RNA helicase it plays a central role in the regulation of fundamental biological processes like RNA stability and translation.
Biological function summary
DDX41 plays a significant role in the innate immune response. It acts as a cytosolic DNA sensor that is involved in the early detection of viral and bacterial DNA. DDX41 interacts with the stimulator of interferon genes (STING) adaptor protein forming an important part of the DNA sensing complex that activates type I interferon responses. By recognizing and binding to foreign DNA within the cytoplasm it helps initiate an antiviral state promoting the activation of immune responses to foreign pathogens.
Pathways
The involvement of DDX41 extends to the innate immune signaling pathway and the type I interferon production pathway. Within these pathways DDX41 interacts directly with other important proteins like STING and TBK1 contributing to the signal transduction that leads to interferon production and subsequent immune activation. These pathways are important for mounting an effective defense against infections connecting DDX41 with the broader regulatory network of proteins involved in pathogen recognition and immune response modulation.
Mutations in the DDX41 gene correlate with certain hematologic conditions including myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). Disruptions in the normal function of DDX41 can affect its role in immune signaling potentially leading to aberrant cell growth and impaired immune functions. Additionally interactions with proteins such as STING during immune responses imply that dysregulation in DDX41 activity could elucidate further insights into other immune-related disorders.