Abcam, ab182127, Anti-PKC delta + PKC theta antibody [EPR17074]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal PKC theta/PRKCQ antibody. Suitable for WB, ICC/IF, IHC-P and reacts with Mouse, Rat, Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR17074,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:WB, IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
PKC delta (Protein Kinase C delta) and PKC theta (Protein Kinase C theta) are members of the Protein Kinase C (PKC) family that function as serine/threonine kinases. These proteins with masses of approximately 78 kDa for PKC delta and 82 kDa for PKC theta play key roles in intracellular signaling processes. PKC delta is expressed in various tissues with particular abundance in heart lung and muscle. PKC theta is mainly found in T cells and skeletal muscle. Both proteins require calcium and diacylglycerol for activation and are often associated with lipid membranes where they exert their enzymatic activity.
Biological function summary
PKC delta and PKC theta regulate diverse cellular processes including proliferation differentiation and apoptosis. PKC delta often participates in programmed cell death and is a part of several signaling cascades initiated by external stress signals. PKC theta is largely recognized for its function in immune response regulation particularly in T cell activation. These proteins are critical in forming signaling complexes with other molecules like scaffold proteins which helps in propagating their functional roles within the cell.
Pathways
PKC delta and PKC theta are integral components of the MAPK (Mitogen-Activated Protein Kinase) and NF-kB (Nuclear Factor kappa-light-chain-enhancer of activated B cells) pathways. In the MAPK pathway PKC delta interacts significantly with proteins such as ERK and MEK mediating cell growth responses. PKC theta activates the NF-kB pathway in lymphocytes enhancing immune response and involving interaction with proteins like IkB kinase (IKK). These contributions show their impact on cellular events through precise regulation of signaling pathways.
PKC delta and PKC theta are linked to cancer and autoimmune diseases. PKC delta's regulation of apoptosis makes it a significant player in tumor suppression with alterations in its activity observed in several types of cancer. In autoimmune diseases such as rheumatoid arthritis PKC theta's role in T cell activity and cytokine production connects it to dysregulated immune responses. Both proteins interact with tumor suppressor p53 in cancer contexts revealing their importance in maintaining cellular equilibrium and responses to dysfunction.