Abcam, ab182136, Anti-beta 2 Adrenergic Receptor antibody [EPR707(N)]

Size: 20µL / 100µL / 1mL
Anti-beta 2 Adrenergic Receptor antibody [EPR707(N)] (ab182136) is a rabbit monoclonal antibody detecting beta 2 Adrenergic Receptor in Western Blot, IHC-P, IHC-Fr . Suitable for Human, Mouse, Rat . - Clone EPR707(N) is the most cited clone to beta 2 Adrenergic Receptor - Biophysical QC for unrivalled batch-batch consistency - Over 50 publications
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR707(N),
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:WB, IHC-P, IHC-FrSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Anti-beta 2 Adrenergic Receptor antibody [EPR707(N)] (ab182136) was developed by Abcam using patented rabbit monoclonal antibody technology and is validated for use in IHC-Fr, IHC-P, WB in human, mouse, rat samples.
Anti-beta 2 Adrenergic Receptor antibody [EPR707(N)] (ab182136) has been cited over 59 times in peer reviewed journals and is trusted by the scientific community.
Abcam's high quality manufacturing and validation processes ensure Anti-beta 2 Adrenergic Receptor antibody [EPR707(N)] (ab182136) has high sensitivity and specificity alongside high lot-to-lot consistency and reproducibility.
Anti-beta 2 Adrenergic Receptor antibody [EPR707(N)] (ab182136) has 5 independent reviews from customers.
Anti-beta 2 Adrenergic Receptor antibody [EPR707(N)] (ab182136) specifically detects beta 2 Adrenergic Receptor (UniProt ID: P07550; Molecular weight: 46kDa) and is sold in a convenient trial size to enable initial testing (20 µL) and larger sizes for subsequent scaling up experiments (100 µL and 1 mL).
Conjugation-ready, carrier free format available for antibody clone EPR707(N) -
ab213651
Antibody clone EPR707(N) is also available pre-conjugated to a variety of labels for your convenience - Alexa Fluor® 647, Alexa Fluor® 488, Alexa Fluor® 594, Alexa Fluor® 568, Alexa Fluor® 555, Alexa Fluor® 750 (
ab225294
ab225295
ab311788
ab313069
ab313266
ab321260
Beta-2 adrenergic receptor (ß2-AR) also known as ADRB2 plays a significant role in immuno-oncology by modulating the immune response and influencing tumor progression. Beta-2 adrenergic receptor signaling can affect both innate and adaptive immune cells, impacting their activation, proliferation, and cytokine production.
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The beta 2 adrenergic receptor (also known as beta-2 adrenergic receptor B2 adrenergic receptor beta-2 receptor) is a transmembrane protein that acts as a receptor for catecholamines like adrenaline and noradrenaline. It belongs to the G protein-coupled receptors (GPCRs) superfamily and is involved in signal transduction by activating adenylate cyclase through the Gs protein. The mass of the beta 2 adrenergic receptor is approximately 46 kDa. This receptor is expressed in various tissues including the lungs skeletal muscle liver and smooth muscle.
Biological function summary
The beta 2 adrenergic receptor is important for mediating the physiological responses to adrenaline and noradrenaline. It plays a significant role in bronchodilation and vasodilation by relaxing airway and vascular smooth muscles. While it does not form a part of any complex its signaling initiates a cascade of intracellular events leading to changes in cellular function. This receptor ensures tissue responsiveness to catecholamines influencing cardiac output metabolic rate and smooth muscle relaxation.
Pathways
This receptor is an important component of the adrenergic signaling pathway and is closely associated with the cAMP-dependent signaling pathway. The activation of the beta 2 adrenergic receptor increases intracellular cAMP levels resulting in the activation of protein kinase A (PKA) and subsequent phosphorylation of various target proteins. The receptor interacts with other proteins within these pathways such as adenylate cyclase and PKA ensuring the propagation of downstream signaling that modulates cellular responses.
The beta 2 adrenergic receptor has a notable connection to asthma and chronic obstructive pulmonary disease (COPD). Its role in bronchodilation makes it a therapeutic target for managing these respiratory conditions. Alterations in the function or expression of the beta 2 adrenergic receptor can exacerbate these diseases. Additionally these disorders demonstrate a link with the muscarinic acetylcholine receptors which also affect airway tone regulation. Understanding the interactions between these receptors is essential for developing therapeutic strategies for respiratory diseases.