Abcam, ab182277, Anti-GluN2C antibody [EPR19094]

Size: 20µL / 100µL / 1mL
Rabbit Recombinant Monoclonal GluN2C antibody. Suitable for WB and reacts with Recombinant fragment, Mouse, Rat, Human samples. Cited in 2 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR19094,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
GluN2C also known as NR2C is a subunit of the NMDA (N-methyl-D-aspartate) receptor an important ion channel in the central nervous system. This protein with a molecular weight of approximately 140 kDa is mainly expressed in the cerebellum and certain thalamic regions of the brain. GluN2C forms part of the ligand-gated ion channels which are important for synaptic transmission and plasticity. By co-assembling with other subunits of NMDA receptors GluN2C plays a vital role in modulating the receptor's response to neurotransmitters like glutamate and glycine.
Biological function summary
NMDA receptors which include the GluN2C subunit perform important functions in calcium ion influx across the cell membrane when activated. This calcium signaling is important for processes such as neuronal development synaptic plasticity and cognitive functions like learning and memory. The NMDA receptor operates as a heterotetrameric complex typically assembled from two GluN1 and two GluN2 (or GluN3) subunits with GluN2C representing one of several variants of the GluN2 subunit.
Pathways
GluN2C plays a role in the glutamatergic signaling pathway which is critical for excitatory neurotransmission in the brain. This pathway includes interactions with proteins such as PSD-95 and CaMKII which are important for synaptic strength and plasticity. Another key pathway is the calcium signaling pathway where GluN2C contributes to calcium-mediated cellular responses influencing neuronal excitability and survival.
GluN2C has associations with neurological conditions like schizophrenia and cerebellar ataxia. Alterations in NMDA receptor function including changes involving the GluN2C subunit can lead to dysregulated synaptic signaling observed in these disorders. In schizophrenia the GluN2C-containing NMDA receptors may interact with synaptic proteins like PSD-95 potentially affecting synaptic architecture and neurotransmitter dynamics. In cerebellar ataxia disruptions in GluN2C expression or function could impair motor coordination emphasizing the importance of proper NMDA receptor function for neurological health.