Abcam, ab18258, Anti-PSD95 antibody - Synaptic Marker

Size: 100µg
Anti-PSD95 antibody - Synaptic Marker (ab18258) is a rabbit polyclonal antibody detecting PSD95 in Western Blot, IHC-P, ICC/IF . Suitable for Human, Mouse, Rat . - Over 360 publications - Trusted since 2005
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:ICC/IF, WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Anti-PSD95 antibody - Synaptic Marker (ab18258) is a rabbit polyclonal antibody and is validated for use in ICC/IF, IHC-P and WB.
Anti-PSD95 antibody - Synaptic Marker (ab18258) was first used in a scientific publication in 2001 and has been cited over 366 times in peer reviewed journals. It's performance in Western blot and IHC in human, mouse and rat samples is trusted by the scientific community.
Abcam's high quality validation processes ensure Anti-PSD95 antibody - Synaptic Marker (ab18258) has high sensitivity and specificity.
The specificity of Anti-PSD95 antibody - Synaptic Marker (ab18258) has been confirmed by WB testing in PSD95 knockout SH-SY5Y cells (
ab280043
Anti-PSD95 antibody - Synaptic Marker (ab18258) has 39 independent reviews from customers.
Anti-PSD95 antibody - Synaptic Marker (ab18258) specifically detects PSD95 (UniProt ID: P78352; Molecular weight: 81kDa) and is sold in 100 ug selling sizes.
PSD95 (Postsynaptic Density Protein 95), encoded by gene DLG4, is a crucial scaffolding protein in neuro research, particularly for its role in synaptic stability and plasticity. It is involved in the organization of synaptic signaling complexes and the regulation of synaptic strength. Researchers use PSD95 to study synaptic development, neurotransmitter receptor localization and the effects of neurological disorders such as stroke and traumatic brain injury (TBI). Its expression helps in understanding synaptic function and the molecular mechanisms underlying synaptic plasticity and neuroprotection.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Protein PSD95 also known as postsynaptic density protein 95 or SAP90 is a significant component in synaptic function. This protein with a molecular mass of approximately 95 kDa is widely expressed in the central nervous system particularly in the postsynaptic terminals of neurons. PSD95 is a member of the membrane-associated guanylate kinase (MAGUK) family and contains three PDZ domains which facilitate its scaffolding ability to assemble large protein complexes at synaptic sites.
Biological function summary
Protein function contributes to the organization and regulation of synaptic signaling complexes. PSD95 is a core component of the postsynaptic density (PSD) an important structure for synaptic signaling and plasticity. The protein interacts directly with NMDA receptors and other synaptic proteins such as Shaker-type K+ channels which enhances synaptic strength and influences synaptic trafficking processes. These interactions are essential for the modulation of synaptic signals and the regulation of synaptic plasticity.
Pathways
Protein PSD95 integrates into several key neuronal signaling pathways. It plays a central role in the glutamatergic synapse as a scaffold protein facilitating receptor clustering and signaling transmission. Through interactions with NMDA receptors and AMPA receptors it modulates synaptic plasticity and long-term potentiation (LTP) critical processes in learning and memory. PSD95 is associated with proteins like stargazin and the guanylate kinase domain which influence synaptic dynamics through complex interactions.
Protein PSD95 plays a role in conditions like schizophrenia and Alzheimer's disease. Dysregulation of PSD95 is linked to impaired synaptic function and cognitive decline in these disorders. In schizophrenia abnormal PSD95 expression disrupts postsynaptic signaling leading to synaptic dysfunction. In Alzheimer's disease PSD95 interacts with amyloid-beta peptides contributing to synaptic deterioration. The protein establishes a connection with other proteins such as tau influencing neurodegeneration pathways.