Abcam, ab18259, Anti-FOXG1 antibody

Size: 100µg
Anti-FOXG1 antibody (ab18259) is a rabbit polyclonal antibody detecting FOXG1 in Western Blot, IHC-P . Suitable for Human, Mouse, Rat . - Over 140 publications - Trusted since 2006
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Specificity:Replenishment batches of our polyclonal antibody, ab18259 are tested in IHC-P. Previous batches were additionally validated in WB. This application is still expected to work and is covered by our Abpromise guarantee. You may also be interested in our alternative recombinant antibody, ab196868.

Product details:
Anti-FOXG1 antibody (ab18259) is a rabbit polyclonal antibody and is validated for use in IHC-P, WB in firefly samples.
Anti-FOXG1 antibody (ab18259) has been cited over 140 times in peer reviewed journals and is trusted by the scientific community.
Abcam's high quality validation processes ensure Anti-FOXG1 antibody (ab18259) has high sensitivity and specificity.
Anti-FOXG1 antibody (ab18259) has 13 independent reviews from customers.
Anti-FOXG1 antibody (ab18259) specifically detects FOXG1 (UniProt ID: P55316; Molecular weight: 52kDa) and is sold in 100 µg selling sizes.
FOXG1 is a critical transcription factor involved in brain development and is associated with various neurological disorders. Research indicates that mutations in FOXG1 can lead to severe developmental issues, making it a significant target for gene therapy. Understanding FOXG1's role can provide insights into potential treatments for conditions like Rett syndrome syndrome.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
FOXG1 also known as Brain Factor 1 (BF-1) is a transcription factor with a molecular weight of approximately 52 kDa. This protein plays an important role in the modulation of gene expression. FOXG1 is found mainly in the developing brain and other tissues of the central nervous system. In adult brains its expression levels significantly decrease although some residual expression persists in areas such as the hippocampus.
Biological function summary
FOXG1 regulates processes of neural development and brain function. It is not known to be part of a protein complex but FOXG1 binds to DNA influencing the transcriptional activity of genes involved in neurogenesis. The protein contributes to the development of structures such as the telencephalon and regulates transitions between different stages of neuronal cell development. Its role extends to maintaining the balance between proliferation and differentiation of neural progenitor cells.
Pathways
FOXG1 participates in the Notch and Wnt signaling pathways. These pathways are critical for cell fate determination and embryonic development. FOXG1 interacts with proteins like those in the Notch pathway to maintain neural progenitors in a proliferative state. In the Wnt signaling pathway FOXG1 helps in modulating the signaling that controls brain patterning working in concert with other transcription factors and signaling molecules.
FOXG1 mutations can lead to congenital conditions such as FOXG1 syndrome and Rett syndrome. In such disorders abnormalities in FOXG1 disrupt normal neural development leading to cognitive and developmental impairments. The involvement of FOXG1 with the MeCP2 protein in Rett syndrome highlights its importance in maintaining normal neurological function. Understanding FOXG1's interactions and functions provides insights into potential therapeutic approaches for these disorders.