Abcam, ab182918, Anti-Forssman antigen antibody [117C9]

Size: 100µg
Rat Monoclonal Forssman antigen antibody. Suitable for IHC-Fr and reacts with Mouse samples. Cited in 1 publication. Immunogen corresponding to Tissue preparation containing Forssman antigen protein.
Key facts
Host species:Rat,
Clonality:Monoclonal,
Clone number:117C9,
Isotype:IgM,
Carrier free:No,
Reacts with:Mouse,
Applications:IHC-FrSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Specificity:ab182918 does not react exclusively with the Forssman antigen. In.a lipid extract fractionated by Folch partition of mouse mammary tumors the antibody also detects other glycolipid.

Properties and Storage Information:
Form-Liquid, Purity-IgM fraction, Storage buffer-Preservative: 0.09% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Forssman antigen also known as heterogenetic antigen functions as a glycolipid present on cell surfaces. This antigen typically consists of a carbohydrate moiety bound to a lipid contributing to its diverse role in biological systems. Forssman antigen is expressed in a variety of species including certain animals and some human cell types. Its molecular mass can vary due to its complex carbohydrate structure which influences its presence and interactions within tissues.
Biological function summary
Forssman antigen participates in intercellular recognition and immune responses. It exists within lipid rafts on cellular membranes and interacts with proteins involved in signal transduction. Although not a protein itself it plays a role when bound in lipid-protein complexes that can activate immune pathways. This antigen provides a form of molecular identification that cells use to communicate and interact with their environment.
Pathways
Forssman antigen interacts significantly with immune system processes and is critical for cellular communication. It appears in the complement pathway where it may interact with proteins such as C1 and C3 during immune responses. Sphingolipid metabolism pathways also involve Forssman antigen due to its linkage to lipid rafts and glycosphingolipids sharing connections with proteins like sphingomyelinase and glycosyltransferases.
Forssman antigen has connections to organ transplant rejection and autoimmune diseases. Its strong antigenic properties can trigger immune responses that jeopardize transplants interacting with proteins such as antibodies in the process. Additionally abnormal expression or recognition of Forssman antigen might contribute to conditions like systemic lupus erythematosus where it links to complement proteins in pathological immune activation.