Abcam, ab183183, Anti-Arc antibody [EPR18950]

Size: 20µL / 100µL / 1mL
Anti-Arc antibody [EPR18950] (ab183183) is a rabbit monoclonal antibody detecting Arc in Western Blot, IP, IHC-P . Suitable for Human, Mouse, Rat . - KO validated for confirmed specificity - Biophysical QC for unrivalled batch-batch consistency
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR18950,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:IHC-P, WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
What is this antibody validated in?
Anti-Arc antibody [EPR18950] (ab183183) is a rabbit recombinant monoclonal antibody and is validated for use in Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC-P) in Human, Mouse, Rat samples.
What is the molecular weight of Arc?
Anti-Arc [EPR18950] (ab183183) specifically detects a band for Arc (UniProt: Q9WV31) at a molecular weight of 45kDa.
Trusted by the scientific community
Anti-Arc [EPR18950] (ab183183) was first used in a scientific publication in 2017 and has been cited over 10 times in peer-reviewed journals.
Trial sizes available!
Test your antibody or perform pre-screening before committing to a larger quantity. Sold in 10µl.
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Specificity confirmed
The specificity of Anti-Arc antibody [EPR18950] (ab183183) has been confirmed by Western blot testing in ARC Knockout Neuro-2a cell line,
ab280071
Other related products
We have a range of other formats of antibody clone [EPR18950] also available for your convenience: ab183183, Carrier free -
ab224717
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The Arc protein also known as Activity-regulated cytoskeleton-associated protein weighs approximately 45 kDa. This protein expresses mainly in the brain specifically in the neurons. It is particularly active in the synaptic regions where it plays a role in synaptic plasticity. The Arc protein belongs to an emerging class of proteins that show similarities with viral proteins. Its structural and functional properties help facilitate the dynamic regulation of synapses and neuronal activity.
Biological function summary
The Arc protein influences synaptic plasticity and memory formation. It does not operate alone; instead it interacts within complexes that regulate synaptic strength. These complexes contain other proteins critical for actin cytoskeleton remodeling which impacts synaptic efficacy. Through these interactions Arc supports the internalization of AMPA receptors playing a role in long-term depression (LTD) and long-term potentiation (LTP) of synapses essential mechanisms for learning and memory.
Pathways
The Arc protein forms integral parts of the synaptic signaling pathways. It connects with the BDNF-TrkB signaling pathway which is important for neuronal development and synaptic modulation. Arc also relates to the mTOR signaling pathway which governs cellular growth and protein synthesis. Through these pathways Arc interacts with proteins like Neuro2a and SynGAP highlighting its comprehensive role in synaptic regulation and plasticity.
Arc protein has a connection to neurological disorders such as Alzheimer's disease and schizophrenia. Researchers found altered Arc expression and function in the brains of affected individuals. These disorders show a link to disrupted synaptic plasticity where Arc plays a significant role. Arc connects to other proteins like Neuro-2a and Caspase-3 in the pathology of these conditions indicating potential targets for therapeutic intervention.