Abcam, ab183247, Recombinant Human LAMTOR4 protein

Size: 20µg
Recombinant Human LAMTOR4 protein is a Human Full Length protein, in the 1 to 99 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE, Mass Spec.
Key facts
Purity:>85% SDS-PAGE,
Expression system:Escherichia coli,
Tags:His tag N-Terminus,
Applications:SDS-PAGE, Mass SpecSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:Q0VGL1,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 10% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

Product details:
Previously labelled as C7orf59.

Properties and Storage Information:
Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
LAMTOR4 also known as late endosomal/lysosomal adaptor and MAPK and MTOR activator 4 is a component of the Ragulator complex. It interacts with specific proteins to anchor the Rag GTPases on lysosomal membranes. LAMTOR4 is a protein with a mass of approximately 11 kDa. Researchers have detected its expression primarily in cellular membranes especially within lysosomes positioning it as key in related processes.
Biological function summary
This protein plays a role in nutrient sensing and cellular growth regulation. LAMTOR4 is part of the Ragulator complex a scaffolding complex essential for the activation of mTORC1 a central regulator of cell growth and metabolism. LAMTOR4 contributes to the recruitment and activation of mTORC1 at the lysosomal surface which is important for the integration of nutrient and energetic signals.
Pathways
LAMTOR4 is involved in the mTOR signaling pathway closely related to cellular metabolism and growth. This protein interacts with other members of the Ragulator complex like LAMTOR1 and LAMTOR2 all connecting in the process of mTORC1 activation. Through the mTOR pathway LAMTOR4 modulates autophagy and anabolic processes therefore maintaining cellular homeostasis.
Alterations in the function of LAMTOR4 have associations with metabolic disorders and cancerous conditions. The regulatory role of LAMTOR4 in mTORC1 activation links it to conditions such as tuberous sclerosis complex where mTOR signaling is disrupted. Alterations in LAMTOR4 and associated proteins like mTOR and other Ragulator complex members can contribute to pathogenesis by disrupting normal cellular growth and metabolism.