Abcam, ab183730, Anti-SNF2H antibody [EPR7673(2)]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal SNF2H antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 5 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR7673(2),
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.2Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SNF2H also known as SMARCA5 is an ATP-dependent chromatin remodeler with a molecular mass of approximately 122 kDa. This protein belongs to the SNF2 family and functions as a motor protein utilizing the energy from ATP hydrolysis to alter chromatin structure. SNF2H expresses widely across multiple tissues with higher expression levels in the brain and reproductive organs. Its mechanical role involves sliding or repositioning nucleosomes along DNA which influences accessibility for transcription replication and repair machinery.
Biological function summary
In coordinating chromatin dynamics and nucleosome architecture SNF2H plays an important part in the ISWI (Imitation Switch) chromatin remodeling complex. This complex modulates chromatin organization to facilitate histone modification and DNA accessibility impacting gene expression regulation. SNF2H directly affects DNA replication and repair processes contributing to the maintenance of genomic stability. The structural flexibility provided by SNF2H is essential for cellular processes where timely and regulated DNA access is necessary.
Pathways
Modulation of chromatin architecture by SNF2H is key to both transcriptional regulation and DNA repair pathways. It participates in the DNA damage response pathway facilitating recruitment and assembly of repair proteins at damage sites. SNF2H also involves itself in transcriptional control through associations with transcription factors and other chromatin contractors such as NURF (Nucleosome Remodeling Factor) complex components which include proteins like BPTF. These interactions permit precise control of gene activation or repression in response to cellular signals.
Dysfunction of SNF2H impacts chromatin remodeling fidelity contributing to conditions such as cancer and developmental anomalies. Aberrations in SNF2H expression or activity can lead to genomic instability influencing cancer progression through altered transcriptional programs and impaired DNA repair mechanisms. Additionally SNF2H links to ATRX syndrome a developmental disorder associated with mutations in the related ATRX protein highlighting its involvement in maintaining chromatin integrity essential for normal development.