Abcam, ab183857, Anti-Spic antibody

Size: 100µL
Rabbit Polyclonal SPIC antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human SPIC aa 1-150.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human SPIC aa 1-150. The exact immunogen used to generate this antibody is proprietary information.Q8N5J4

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.025% Proclin 300Constituents: PBS, 20% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The Spi-C transcription factor also known as Spic or Spi-C has a mass of approximately 35 kDa. Spic functions as a transcription factor which means it binds to DNA to regulate the expression of specific genes. It is mostly expressed in cells of the mononuclear phagocyte system like macrophages and dendritic cells as well as in B cells. Expression levels can vary depending on the tissue type and the presence of cytokines which can modulate its expression.
Biological function summary
The role of Spic is important for the differentiation and function of red pulp macrophages in the spleen. It belongs to the E26 transformation-specific (Ets) family of transcription factors each recognized for guiding particular cellular processes. While Spic acts alone its activity influences how monocytes mature into macrophages. Spic manages the expression of genes that encode enzymes required for heme catabolism a vital process for iron recycling within the spleen.
Pathways
The activity of Spic impacts the erythrophagocytosis pathway which is related to the clearance of aged or damaged red blood cells and the heme degradation pathway. By regulating heme oxygenase-1 (HO-1) Spic assists in breaking down heme so that iron can be reclaimed by the body. This role connects Spic with other proteins in the erythrophagocytosis pathway like HO-1 highlighting its importance in maintaining iron homeostasis and proper cellular function.
Spic holds relevance in anemia and certain autoimmune conditions. Its involvement in iron metabolism through erythrophagocytosis implies that any dysregulation might contribute to iron-loading conditions such as anemia of inflammation. Moreover altered Spic expression or function can impact autoimmune disorders where macrophage activity is aberrant. In these contexts Spic interacts with proteins such as HO-1 and may further participate in pathway dysregulation leading to disease states.