Abcam, ab183911, Anti-CEP152 antibody

Size: 100µL
Rabbit Polyclonal CEP152 antibody. Suitable for IP, WB, ICC/IF and reacts with Human samples. Cited in 12 publications. Immunogen corresponding to Recombinant Fragment Protein within Human CEP152 aa 50-300.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IP, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human CEP152 aa 50-300. The exact immunogen used to generate this antibody is proprietary information.O94986

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: PBS, 20% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CEP152 also known as centrosomal protein of 152 kDa is a component of the centrosome and plays a critical mechanical role in cell division. It weighs approximately 152 kilodaltons and is expressed in various tissues primarily during the cell cycle. CEP152 functions as a scaffold protein aiding in the recruitment and organization of other proteins involved in centrosome-related processes. These activities make it an essential player in maintaining centrosome integrity and ensuring the correct duplication of centrioles which are pivotal for proper spindle formation and chromosome segregation.
Biological function summary
The protein plays a significant role in the regulation of genomic stability and cell cycle progression. It forms part of a complex with other centrosomal proteins such as CEP63 which further enhances its role in centrosome duplication. This cooperation between proteins ensures that cells properly manage centrosome replication and prevent abnormalities that could lead to genomic instability. CEP152 also interacts with kinases to modulate centrosomal activities and help maintain genetic fidelity during cell division.
Pathways
CEP152 integrates into the centrosome cycle and DNA damage response pathways. The protein actively participates in centrosome assembly working in conjunction with proteins like CEP192 to control centriole duplication and maturation. Additionally CEP152 influences the ATR signaling pathway which is a critical pathway for responding to DNA damage and maintaining cell cycle checkpoints. Through these interactions CEP152 helps synchronize cell cycle events with DNA repair processes therefore ensuring cellular homeostasis.
CEP152 links to microcephalic primordial dwarfism and certain cancers. Mutations in CEP152 can lead to reduced brain size and associated developmental disorders connecting it with the disease condition microcephalic osteodysplastic primordial dwarfism type I (MOPD I). In cancer altered expressions of CEP152 have been implicated in tumorigenesis often due to its association with the misregulation of cell cycle pathways. The protein's connection to PLK4 a pivotal regulator of centriole duplication highlights its importance in maintaining centrosomal functions and its potential role in cancer when these processes go awry.