Abcam, ab184009, Anti-STAU2 antibody

Size: 100µL
Rabbit Polyclonal STAU2 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human, Mouse, Rat samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human STAU2 aa 1-250.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human, Rat,
Applications:IHC-P, ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human STAU2 aa 1-250. The exact immunogen used to generate this antibody is proprietary information.Q9NUL3

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
STAU2 also known as Staufen double-stranded RNA-binding protein 2 is a protein that plays a mechanical role in RNA binding and localization. It weighs approximately 62 kDa and is expressed widely especially in neuronal tissues. The protein has several RNA recognition motifs that allow it to bind with different RNA molecules facilitating the transport and localization of mRNA within cells. This function is critical for cellular processes like mRNA stability and translation regulation.
Biological function summary
STAU2 influences dynamic cellular processes like the regulation of mRNA degradation and localization contributing to protein synthesis in neurons. It operates as part of a ribonucleoprotein complex which includes other proteins like UPF1 that are important for mRNA surveillance. This complex works to ensure mRNA molecules are properly recognized and processed within the cell highlighting the role of STAU2 in maintaining cellular homeostasis.
Pathways
There is a good integration between STAU2 and molecular pathways such as nonsense-mediated mRNA decay and synaptic plasticity. STAU2 associates with the NMD pathway modulating the degradation of aberrant mRNAs and protecting the cell from dysfunctional proteins. Cells use this interaction with UPF1 and other NMD components to maintain genetic quality control highlighting the coordination between STAU2 and these pathways for proper cellular function.
STAU2 shows relevance to neurological disorders particularly those involving synaptic dysfunction. Aberrations in STAU2 activity are linked to conditions such as schizophrenia and autism spectrum disorders. In the context of these diseases STAU2 interacts with proteins involved in synaptic formation and maintenance highlighting its importance in brain function. STAU2's connection to conditions like these highlights its potential as a target for therapeutic intervention in neurodegenerative diseases.