Abcam, ab184032, Anti-ACOX1/AOX antibody [EPR19038]

Size: 20µL / 100µL / 1mL
Anti-ACOX1/AOX antibody [EPR19038] (ab184032) is a rabbit monoclonal antibody detecting ACOX1/AOX in Western Blot, Flow Cytometry (Intra), Flow Cytometry, IP, ICC/IF . Suitable for Human, Mouse, Rat . - Biophysical QC for unrivalled batch-batch consistency - Over 30 publications
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR19038,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:ICC/IF, IP, WB, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
What is this antibody validated in?
Anti-ACOX1/AOX antibody [EPR19038] (ab184032) is a rabbit recombinant monoclonal antibody and is validated for use in Western Blot (WB), Flow Cytometry (Intra), Flow Cytometry (Flow Cyt), Immunoprecipitation (IP), Immunocytochemistry/immunofluorescence (ICC/IF) in Human, Mouse, Rat samples.
What is the molecular weight of ACOX1/AOX?
Anti-ACOX1/AOX [EPR19038] (ab184032) specifically detects a band for ACOX1/AOX (UniProt: Q9R0H0) at a molecular weight of 75kDa.
Trusted by the scientific community
Anti-ACOX1/AOX [EPR19038] (ab184032) was first used in a scientific publication in 2015 and has been cited over 30 times in peer-reviewed journals.
Trial sizes available!
Test your antibody or perform pre-screening before committing to a larger quantity. Sold in 10µl.
Discover our selection of trial-size antibodies
Other related products
We have a range of other formats of antibody clone [EPR19038] also available for your convenience: ab184032, Carrier free -
ab238939
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ACOX1 also known as AOX or AOX animal plays an important role in peroxisomal beta-oxidation of fatty acids. This enzyme catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs. ACOX1 with a mass of approximately 73 kDa is primarily expressed in liver and kidney tissues where it contributes to lipid metabolism. The functionality of this protein is essential for maintaining the balance of fatty acids within the peroxisome which is an important organelle in cellular lipid homeostasis.
Biological function summary
ACOX1 functions as part of the fatty acid oxidation process by ensuring the efficient breakdown of very long-chain fatty acids. This enzyme operates in conjunction with other proteins involved in the beta-oxidation enzyme complex. The activity of ACOX1 is significant for energy production metabolizing long-chain fatty acids which accumulate under normal physiological conditions. Proper function of this enzyme ensures that excessive accumulation of these fatty acids does not occur which can otherwise lead to cellular stress or dysfunction.
Pathways
ACOX1 fits into lipid metabolism pathways specifically the peroxisomal beta-oxidation pathway. This pathway is critical for the breakdown of long and very long-chain fatty acids. ACOX1 functions together with other peroxisomal enzymes such as peroxisomal acyl-coenzyme A oxidase 2 (ACOX2) to complete this metabolic process. Both these enzymes work in tandem to manage fatty acid levels within the peroxisomal pathway ensuring smooth cellular energy homeostasis and overall metabolic function.
Mutations or deficiencies in ACOX1 relate closely to conditions like adrenoleukodystrophy and Zellweger syndrome. These disorders arise from impaired peroxisomal function leading to the accumulation of very long-chain fatty acids that are typically processed by ACOX1. Such accumulations can exacerbate neurological and hepatic disorders. Additionally a dysfunctional interaction between ACOX1 and peroxisomal protein peroxin 1 (PEX1) can result in compromised peroxisome function further contributing to the pathology of these disorders.