Abcam, ab184563, Anti-SNAP-beta antibody [EPR15046(B)] - N-terminal

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal SNAP-beta antibody. N-terminal. Suitable for IP, WB and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR15046(B),
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SNAP-beta also known as SNAP-23 is part of the SNARE family consisting of about 23 kDa proteins. This protein plays a role in vesicular transport processes working in the docking and fusion of vesicles with membranes. Expressed broadly in mammalian tissues SNAP-beta shows higher levels in brain and adipose tissue indicating its involvement in vital cellular functions across various organs.
Biological function summary
SNAP-beta contributes to the regulation of membrane trafficking essential for processes such as neurotransmitter release and insulin-mediated glucose uptake. It acts as a member of the SNARE complex alongside syntaxin and VAMP proteins facilitating membrane fusion within cells. This functional integration within a complex highlights its significance in efficient intracellular communication.
Pathways
Vesicular transport and exocytosis highlight the overlapping roles of SNAP-beta within the cell. SNAP-beta engages in these pathways by interacting with proteins like syntaxin 4 and synaptobrevin. This linkage ensures precise membrane fusion events necessary for effective cellular responses and functions.
SNAP-beta has associations with type 2 diabetes and neurological disorders. Altered SNAP-beta function can cause disruptions in insulin signaling and neurotransmitter release contributing to these conditions. It often interacts with proteins like GLUT4 affecting glucose metabolism and synaptic transmission underlining its involvement in related pathophysiological states.