Abcam, ab18465, Anti-Ctip2 antibody [25B6]

Size: 100µg
Anti-Ctip2 antibody [25B6] (ab18465) is a rat monoclonal antibody detecting Ctip2 in Western Blot, Flow Cytometry, IHC-P, ICC/IF . Suitable for Human, Mouse . - Clone 25B6 is the most cited clone to Ctip2 - Over 840 publications - Trusted since 2005
Key facts
Host species:Rat,
Clonality:Monoclonal,
Clone number:25B6,
Isotype:IgG2a,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:Flow Cyt, ICC/IF, WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human BCL11B. The exact immunogen used to generate this antibody is proprietary information.Q9C0K0,
Epitope:Between amino acids 1-150 of CTIP2.,
Specificity:Detects 2 bands representing Ctip2 at about 120kD. Ctip2 is highly expressed in brain and in malignant T-cell lines derived from patients with adult T-cell leukemia/lymphoma.

Product details:
Anti-Ctip2 antibody [25B6] (ab18465) is a rat monoclonal antibody and is validated for use in Flow Cyt (Intra), ICC/IF, IHC-P and WB.
Anti-Ctip2 antibody [25B6] (ab18465) was first used in a scientific publication in 2001 and has been cited over 841 times in peer reviewed journals. It's performance in immunofluorescence and IHC in human and mouse samples is trusted by the scientific community.
Abcam's high quality validation processes ensure Anti-Ctip2 antibody [25B6] (ab18465) has high sensitivity and specificity.
Anti-Ctip2 antibody [25B6] (ab18465) has 35 independent reviews from customers.
Anti-Ctip2 antibody [25B6] (ab18465) specifically detects Ctip2 (UniProt ID: Q9C0K0; Molecular weight: 96kDa) and is sold in 100 µg selling sizes.
Antibody clone 25B6 is also available pre-conjugated to a variety of labels for your convenience - FITC (
ab123449
CTIP2, also known as BCL11B, is a transcription factor crucial in neuro research for its role in neural development and differentiation. It is particularly important for the development of medium spiny neurons (MSNs) in the striatum, which are essential for motor control and are affected in conditions like Huntington's disease. CTIP2 regulates gene expression involved in neuronal differentiation, axon guidance and synaptic connectivity, making it vital for understanding the cellular architecture and function of the nervous system.

Properties and Storage Information:
Form-Liquid, Purification technique-Multi-step chromatography, Storage buffer-pH: 7.5Preservative: 0.02% Sodium azideConstituents: 0.87% Sodium chloride, 0.357% HEPES, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Ctip2 also known as Bcl11b is a transcription factor with a molecular mass of approximately 101 kDa. Researchers study Ctip2 for its critical role in gene regulation. It is highly expressed in the brain thymus and skin reflecting its diverse functional roles in different tissues. Ctip2 plays an important role in the development and differentiation of neurons as well as T-cells in the immune system. The ability to track its expression using ctip2 staining provides important insights into developmental biology.
Biological function summary
Ctip2 protein acts as an important regulator in various cellular processes such as immune function neural development and skin differentiation. As a part of a transcriptional complex it interacts with other proteins to modulate gene expression important for cell fate determination. This protein represses and activates target genes to ensure proper neuronal development and immune system maturation. The presence of Ctip2 marker helps in identifying specific cell lineages during development and differentiation studies.
Pathways
Ctip2 protein influences multiple biological pathways that are important for cellular differentiation and development. It is notably involved in the Notch signaling and Wnt signaling pathways which are vital for cell communication and developmental processes. In the context of these pathways Ctip2 interacts closely with other proteins such as TCF-1 and Gata3 which are also involved in differentiation processes. These interactions allow Ctip2 to maintain proper physiological functions by affecting precise gene networks.
Ctip2 has been implicated in immune-related disorders and neurological conditions. Aberrant expression of Ctip2 is associated with T-cell malignancies which makes it a target of interest for therapeutic interventions. Its role in neuronal differentiation connects it to neurodevelopmental disorders including autism spectrum disorders. Interaction with proteins like Gata3 and TCF-1 highlights the potential of Ctip2 as a therapeutic target as these links could help in understanding and developing strategies to address these conditions.