Abcam, ab184772, Anti-URG11 antibody

Size: 100µL
Rabbit Polyclonal URG11 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human VWCE aa 400-550.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human VWCE aa 400-550. The exact immunogen used to generate this antibody is proprietary information.Q96DN2

Properties and Storage Information:
Form-Liquid, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Urg11 also known as upregulated gene 11 or LncRNA-URHC is a protein with a molecular weight of approximately 42 kDa. This protein has notable expression in several tissues including the liver and kidney. It plays a significant role at the cellular level by interacting with other proteins to facilitate various molecular processes. Researchers often study URG11 for its involvement in cell proliferation and tumor progression.
Biological function summary
The role of URG11 extends beyond a singular function. This protein contributes to the regulation of cell growth and differentiation indicating its involvement in cellular proliferation and tissue development. URG11 acts in coordination sometimes as part of larger complexes to exert its effects on these biological processes. It interacts with key signaling molecules to influence downstream biological outcomes.
Pathways
URG11 engages prominently in pathways related to cell signaling particularly the Wnt/β-catenin signaling pathway. This involvement sees URG11 interacting with critical proteins like β-catenin impacting gene transcription and cellular adhesion processes. Studies show that URG11 also has ties to pathways concerning cell cycle regulation revealing its interconnectedness with proteins involved in cell cycle progression.
URG11 exhibits a significant association with liver cancer particularly hepatocellular carcinoma. Its overexpression correlates with tumor growth making it a potential biomarker for diagnosis and prognosis. URG11 is also linked to renal diseases where it may influence pathogenesis through interactions with proteins such as β-catenin and other signaling molecules. These connections highlight its role in disease development and suggest potential therapeutic targets.