Abcam, ab184777, Anti-ST8SIA5 antibody

Size: 100µL
Rabbit Polyclonal ST8SIA5 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ST8SIA5 aa 300 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human ST8SIA5 aa 300 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.O15466

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-Up to 12 months, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ST8SIA5 also known as ST8 alpha-N-acetyl-neuraminide alpha-28-sialyltransferase 5 is an enzyme involved in sialylation a process that adds sialic acid to glycoproteins and glycolipids. This enzyme which has a molecular mass of approximately 45 kDa facilitates the transfer of sialic acid through alpha-28 glycosidic linkages. It shows expression in various tissues including the brain placenta and skeletal muscles. The expression levels of ST8SIA5 vary among tissues impacting its functional roles in those regions.
Biological function summary
ST8SIA5 influences cell-cell interactions modulation of immune responses and neural plasticity by altering cell surface molecules. It contributes to polysialylation integrating into glycan structures on cell membranes. Although it is not part of a larger complex it cooperates with other sialyltransferases to determine the complexity of sialic acid structures which affect cellular behavior.
Pathways
Sialylation by ST8SIA5 plays a significant role in the neural development and the regulation of immune responses. It interacts with pathways involving cell adhesion molecules influencing neuronal growth and migration. ST8SIA5 operates alongside proteins such as NCAM1 and ST8SIA2 impacting cell adhesion and signaling processes important in neural development and synaptic functions.
ST8SIA5 has associations with neurodevelopmental disorders and certain cancers. Alterations in its sialyltransferase activity may link to schizophrenia where it possibly interacts with proteins like NCAM1 to impact neural connectivity. Additionally variations in ST8SIA5 expression levels have been observed in tumor progression implicating a role in cellular transformation and metastasis potentially involving interactions with glycoproteins in cancer cells.