Abcam, ab184829, Anti-KATNAL2 antibody

Size: 100µL
Rabbit Polyclonal KATNAL2 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human KATNAL2 aa 150-300.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human KATNAL2 aa 150-300. The exact immunogen used to generate this antibody is proprietary information.Q8IYT4

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
KATNAL2 also known by its official full name Katanin catalytic subunit A-like 2 is a protein involved in microtubule severing. It possesses a molecular mass of approximately 63 kDa. KATNAL2 is expressed in various tissues throughout the body with notable expression in the brain and reproductive organs. This protein is important for the regulation of the cytoskeleton through the disassembly of microtubules contributing to cellular structure maintenance.
Biological function summary
KATNAL2 plays a role in cellular processes like mitosis and neuronal development. As part of a larger protein complex it interacts with other proteins to facilitate its microtubule severing activity. This action helps in remodeling the microtubule network which is essential for cellular dynamics and morphological changes during cell division and differentiation. The precise assembly and disassembly controlled by KATNAL2 are important for ensuring normal cell function and development.
Pathways
KATNAL2 associates with the microtubule dynamics pathway and is involved in mitotic spindle organization. It interacts with proteins such as katanin p60 which assists in severing microtubules. This interaction allows for the correct segregation of chromosomes during cell division. Additionally KATNAL2 may influence signaling pathways related to cytoskeletal organization demonstrating its importance in maintaining cellular integrity.
Changes in KATNAL2 function link to neurodevelopmental disorders and male infertility. Abnormal expression levels of KATNAL2 have implications in conditions affecting neuronal development where its role alongside proteins such as the tubulin family becomes apparent. Disruption in these pathways related to KATNAL2 can lead to disorders characterized by improper neuronal connections or alterations in testicular structure leading to infertility. Understanding KATNAL2's interaction with related proteins sheds light on its impact on these diseases.